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RAS Chemistry & Material ScienceХимия высоких энергий High Energy Chemistry

  • ISSN (Print) 0023-1193
  • ISSN (Online) 3034-6088

Effect of gamma-irradiation of papain on physicochemical properties of its aqueous solutions

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PII
S30346088S0023119325050054-1
DOI
10.7868/S3034608825050054
Publication type
Article
Status
Published
Authors
A.R. Gataullin
  • Affiliation: Kazan National Research Technological University
S.A. Bogdanova
  • Affiliation: Kazan National Research Technological University
A.E. Shevyakova
  • Affiliation: Kazan National Research Technological University
S.V. Demidov
  • Affiliation: Federal Research Center for Problems of Chemical Physics and Medical Chemistry of the Russian Academy of Sciences
S. R. Allayarov
  • Affiliation: Federal Research Center for Problems of Chemical Physics and Medical Chemistry of the Russian Academy of Sciences
Volume/ Edition
Volume 59 / Issue number 5
Pages
336-343
Abstract
The effect of γ-irradiation of papain with doses from 30 to 700 kGy on light absorption in the UV and visible regions, isoelectric state, viscosity, surface tension and electrical conductivity of its aqueous solutions has been studied. It is shown that the increase of irradiation dose of papain on the one hand is accompanied by the increase of absorption in the UV and visible regions, as well as by the increase of electrical conductivity, on the other hand, the increase of irradiation dose of papain is accompanied by the decrease of viscosity and surface tension of its solutions. The main reasons for such changes are the destruction of peptide bonds in papain during radiolysis and reduction of its molecular weight, radiation-induced oxidation of amino acid residues and formation of carbonyl derivatives, as well as the formation and accumulation in papain macromolecules of various terminal primary amino groups carrying a positive charge.
Keywords
папаин γ-облучение физико-химические свойства светопропускание изоэлектрическое состояние вязкость поверхностное натяжение электропроводность
Date of publication
01.05.2025
Year of publication
2025
Number of purchasers
0
Views
16

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